Regular Season Conference Championships | University of Saint Francis (Ind.)

• Mid-States Football Association
  • Football (15): 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2008, 2012, 2013, 2015, 2017, 2024, 2025
• Mid-Central College Conference
  • Volleyball (1): 2003
  • Softball (1): 1997
  • Men's Basketball (2): 1979-1980, 1999-2000
  • Women's Basketball (6): 1996-1997, 1997-1998, 1998-1999, 1999-2000, 2001-2002, 2005-2006
  • Men's Soccer (2): 1977, 2003
  • Women's Soccer (5): 1997, 1998, 2000, 2001, 2003
  • Men's Golf (1): 1980
• Crossroads League
  • Men's Basketball (1): 2015-16
  • Women's Basketball (2): 2012-13, 2013-14

* On June 27, 2012, the Mid-Central College Conference changed its name to the Crossroads League. League Commissioner J.D. Collins initiated a rebrand effort to update and revive the identity of the Central Indiana-based athletic conference.

Conference Tournament Championships | University of Saint Francis (Ind.)

• Crossroads League
  • Women's Soccer (1): 2005
  • Men's Basketball (2): 20015-16, 2010-11
  • Women's Basketball (3): 2013-14, 2012-13, 2005-06
  • Softball (1): 2026